What does galvanic skin response measure3/16/2024 Many of the published results violate biologic plausibility. Prior studies do not support claims that ESC is a measure of small fiber sensory function or autonomic function.Īlthough many papers report significant differences in ESC values between disease and control subjects, the compiled data assessed in this review raises questions about the technique. The extracted data did not agree with other published normative values. Of the 37 studies assessed, 25 received support from the device manufacturer. Longitudinal studies of disease demonstrated changes in ESC that were not biologically plausible. ESC did not change by age or gender, and there was significant variability in ESC values between diseases, some of which exceeded control values. Thirty-seven studies were included this systematic review. The search strategy included the following terms: "electrochemical skin conductance," "EZSCAN," and "Sudoscan." The data values provided by each paper were extracted, where available, and input into tabular and figure data for direct comparison. Here we systematically review the evolution of this device and the data obtained from studies of ESC across different diseases.Įlectronic databases, including MEDLINE, and Google Scholar were searched through to February 2018. Electrochemical skin conductance (ESC) is a non-invasive test of sweat function developed as a potential marker of small fiber neuropathy.
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